QRFPR antibody

Catalog No. ABIN317864

The Rabbit Polyclonal anti-QRFPR antibody is suitable to detect QRFPR in samples from Human, Mouse and Rat. It has been validated for WB, IF and EIA.

Quick Overview for QRFPR antibody (ABIN317864)

Target: QRFPR (Pyroglutamylated RFamide Peptide Receptor (QRFPR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This QRFPR antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Product Details anti-QRFPR Antibody

Specificity: GPR103 antibody detects endogenous levels of GPR 103 protein.(region surrounding Ile310)

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1/10000approx. 1/20000. Western Blot: 1/500approx. 1/1000. Immunofluorescence: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for QRFPR

Target: QRFPR (Pyroglutamylated RFamide Peptide Receptor (QRFPR))

Alternative Name: QRFPR / GPR103

Background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane-spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR103 is a 455 amino acid protein with highest expression in the brain, retina, trigeminal ganglion, hypothalamus and vestibular nucleus. In peripheral tissues, GPR103 is expressed only in the heart, kidney and testis. GPR103 may regulate adrenal function. A hypothalamic neuropeptide of the RFamide family (26RFa) acts as an endogenous ligand for GPR103.Synonyms: AQ27, G-protein coupled receptor 103, Orexigenic neuropeptide QRFP receptor, Pyroglutamylated RFamide peptide receptor, SP9155

Molecular Weight: approx. 49 kDa

Gene ID: 84109

NCBI Accession: NP_937822

UniProt: Q96P65