CPN1 antibody
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- Target See all CPN1 Antibodies
- CPN1 (Carboxypeptidase N Subunit 1 (CPN1))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CPN1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Specificity
- CPN cat antibody detects endogenous levels of CPN cat protein.(region surrounding Gln452)
- Purification
- Affinity chromatography
- Top Product
- Discover our top product CPN1 Primary Antibody
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- Application Notes
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- CPN1 (Carboxypeptidase N Subunit 1 (CPN1))
- Alternative Name
- Carboxypeptidase N Catalytic Chain (CPN1 Products)
- Synonyms
- CPN antibody, SCPN antibody, Cpn antibody, cb1037 antibody, fa99g08 antibody, wu:fa99g08 antibody, zgc:77485 antibody, cpn antibody, scpn antibody, 0610011F20Rik antibody, carboxypeptidase N subunit 1 antibody, carboxypeptidase N, polypeptide 1 antibody, carboxypeptidase N subunit 1 S homeolog antibody, CPN1 antibody, Cpn1 antibody, cpn1 antibody, cpn1.S antibody
- Background
- Carboxypeptidase N (arginine carboxypeptidase or CPN) cleaves basic amino acid residues from the carboxy terminal of peptides and proteins. The enzyme plays a central role in regulating the biologic activity of peptides such as kinins and anaphylatoxins, and therefore is also known as kininase-1 and anaphylatoxin inactivator. CPN is a tetrameric complex consisting of two identical regulatory subunits (CPN reg) and two identical catalytic subunits (CPN cat). The two glycosylated CPN reg subunits protect the two CPN cat subunits and keep them in the circulation. CPN reg is a member of the leucinerich repeat family of proteins and the gene which encodes CPN reg maps to human chromosome 8p22-p23. CPN cat is a member of the regulatory B-type carboxypeptidase group and the gene which encodes CPN cat maps to human chromosome 10.Synonyms: ACBP, Anaphylatoxin inactivator, Arginine carboxypeptidase, CPN, CPN1, Carboxypeptidase N polypeptide 1, Carboxypeptidase N small subunit, Kininase-1, Lysine carboxypeptidase, Plasma carboxypeptidase B, SCPN, Serum carboxypeptidase N
- Molecular Weight
- approx. 52 kDa
- Gene ID
- 1369
- NCBI Accession
- NP_001299
- UniProt
- P15169
- Pathways
- Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, C21-Steroid Hormone Metabolic Process
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