KCNK1 antibody

Catalog No. ABIN317929

This Rabbit Polyclonal antibody specifically detects KCNK1 in WB. It exhibits reactivity toward Human and Rat.

Quick Overview for KCNK1 antibody (ABIN317929)

Target: KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-KCNK1 Antibody

Specificity: This antibody detects endogenous levels of TWIK-1 protein.(region surrounding Val322)

Purification: Affinity Chromatography using epitope-specific immunogen

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 with 0.05 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KCNK1

Target: KCNK1 (Potassium Channel Subfamily K Member 1 (KCNK1))

Alternative Name: KCNK1

Background: K+ channels are divided into three subclasses, reflecting the number of transmembrane segments (TMS), which are designated 6TMS, 4TMS and 2TMS. Members of the 4TMS class contain two distinct pore regions, and include TASK, TREK, TRAAK and TWIK. TWIK-1 mRNA is expressed abundantly in brain and at lower levels in lung, kidney and skeletal muscle. The molecular weight of TWIK-1 in mouse brain is 40 kDa under reducing conditions. TWIK-2 shares low sequence homology with other mammalian family group members, and only 34 % homology with TWIK-1. Human TWIK-2 is expressed in pancreas, placenta and heart, while mouse TWIK-2 is expressed in liver. TWIK-2 is inhibited by intracellular, but not extracellular, acidification.Synonyms: HOHO1, Inward rectifying potassium channel protein TWIK-1, KCNK1, KCNO1, Potassium channel KCNO1, Potassium channel subfamily K member 1, TWIK1

Molecular Weight: approx. 38 kDa

Gene ID: 3775

NCBI Accession: NP_002236

UniProt: O00180