HCN2 antibody

Catalog No. ABIN317931

The Rabbit Polyclonal anti-HCN2 antibody (ABIN317931) specifically detects HCN2 in WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for HCN2 antibody (ABIN317931)

Target: HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HCN2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-HCN2 Antibody

Specificity: HCN2 antibody detects endogenous levels of HCN2 protein.(region surrounding Glu521)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HCN2

Target: HCN2 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 2 (HCN2))

Alternative Name: HCN2 / BCNG2

Background: Hyperpolarization-activated, cyclic nucleotide-binding channels (HCN) are voltage-gated cation channels that are activated by direct binding of intracellular cyclic nucleotides. The HCN family consists of four members (HCN1-4), each with a core transmembrane segment domain and a carboxy-terminal 120 amino-acid cyclic nucleotide-binding domain motif. HCN channels are expressed in the brain, heart, thalamus and testis. The pacemaker properties of HCN channels contribute to spontaneous rhythmic activity in the brain and heart. The genes encoding human HCN1 and HCN2 map to chromosomes 5 and 19p13.3, respectively. The genes encoding HCN3 and HCN4 map to chromosomes 1q21.3 and 15q24-q25, respectively.Synonyms: Brain cyclic nucleotide-gated channel 2, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Molecular Weight: approx. 100 kDa

Gene ID: 610

NCBI Accession: NP_001185

UniProt: Q9UL51