KNG1 antibody

Catalog No. ABIN318367

This Goat Polyclonal antibody specifically detects KNG1 in EIA. It exhibits reactivity toward Human and Vicia faba.

Quick Overview for KNG1 antibody (ABIN318367)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human, Vicia faba

Host: Goat

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Product Details anti-KNG1 Antibody

Sequence: RPPGFSPFR

Specificity: This antibody is specific for Bradykinin and Lys-Bradykinin (kallidin).

Purification: Purified IgG prepared by affinity chromatography on Protein G

Immunogen: Bradykinin peptide conjugated to c.BSA

Isotype: IgG

Application Details

Application Notes: ELISA
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 5.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: Kininogen-1

Background: Bradykinin is a nine amino acid vasoactive peptide which elicits numerous physiologic responses such as vasodilation, smooth muscle spasm and pain. Bradykinin is one of a family of such peptides called the kinins. These kinins are generated by proteolysis of high molecular weight precursors called kininogens upon activation by pathophysiologic conditions such as inflammation or allergy. The physiological actions of these kinins are brought about through their interaction with transmembrane receptors. There are two distinct bradykinin receptor subtypes, B1 and B2, both of which appear to be coupled to G-proteins. The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas the B1 receptors are only detected following tissue injury. The B2 receptor is similar in structure to other seven helix G protein coupled receptors. Bradykinin has relatively low affinity for B1 receptors, interacting primarily with the B2 receptor through which several second messenger systems are stimulated, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and hyperpolarization.Synonyms: Bradykinin, Kallidin-1, Kallidin-I, Kallidin1

Gene ID: 3827

NCBI Accession: NP_000884

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process