Cadherin 13 antibody (N-Term)

Catalog No. ABIN318711

The Rabbit Polyclonal anti-Cadherin 13 antibody (ABIN318711) specifically detects Cadherin 13 in WB and IF. The antibody is reactive with Human and Mouse samples.

Quick Overview for Cadherin 13 antibody (N-Term) (ABIN318711)

Target: Cadherin 13 (CDH13)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 13 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-Cadherin 13 Antibody

Binding Specificity: N-Term

Specificity: This antibody recognises T-Cadherin.

Purification: Affinity Chromatography.

Immunogen: Synthetic peptide corresponding to N-terminus of human Cadherin-13.

Isotype: IgG

Application Details

Application Notes: Western Blot (0.5-1.0 μg/mL): This antibody detects a band/s of approximately 78 kDa in3T3 cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid multiple freeze/thaw cycles.

Target Details for Cadherin 13

Target: Cadherin 13 (CDH13)

Alternative Name: Cadherin-13

Background: T-cadherin is a 78 kDa, calcium-dependent, glycoprotein. While T-cadherin is a member of the cadherin family, it lacks their conserved cytoplasmic region, being instead anchored to the plasma membrane via glycosylphosphatidylinositol linkage. It is expressed in the heart and CNS with the exception of the cerebellum and spinal cord. Cadherin 13 is classified as a cell-cell adhesion molecule, although it is likely that it's role is in signalling and not physical adhesion. It is involved in regulating low-density lipoprotein-initiated cell proliferation, keratinocyte proliferation, neural cell growth and may play a role in metabolic regulation. Cadherin 13 protects endothelial cells from oxidative stress-induced apoptosis and may contribute to progression of vascular disorders such as atherosclerosis, restenosis and tumour angiogenesis.Synonyms: CDH13, CDHH, Cadherin H, Cadherin T, H-Cadherin, Heart cadherin, P105, T-Cadherin, Truncated cadherin

Gene ID: 1012

NCBI Accession: NP_001248

UniProt: P55290

Pathways: EGFR Signaling Pathway, Cell-Cell Junction Organization