BAG1 antibody (C-Term)

Catalog No. ABIN318738

The Rabbit Polyclonal anti-BAG1 antibody (ABIN318738) specifically detects BAG1 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for BAG1 antibody (C-Term) (ABIN318738)

Target: BAG1 (BCL2-Associated Athanogene (BAG1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAG1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-BAG1 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects an epitope within the C-terminal (CT) region of Bcl-2 associated athanogene-1 (BAG1).

Purification: Purified

Immunogen: 14 amino acid peptide from near the carboxy terminus of human BAG1.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1 - 2g/mL, detects a band of approximately 39 kDa in PC3 cell lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for BAG1

Target: BAG1 (BCL2-Associated Athanogene (BAG1))

Alternative Name: BAG1

Background: BAG1 is a co-chaperone protein which binds to and regulates the 70kD heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival. The BAG1 gene encodes three different isoforms, a predominantly cytosolic form of 36kD (BAG1S), a 46kD cytosolic and nuclear form (BAG1M), and a predominantly nuclear form 50kD (BAG1L). BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.Synonyms: BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP, RAP46

Gene ID: 573

NCBI Accession: NP_001165886

UniProt: Q99933