TNNI3 antibody

Catalog No. ABIN318833

The Goat Polyclonal anti-TNNI3 antibody is suitable to detect TNNI3 in samples from Human. It has been validated for EIA.

Quick Overview for TNNI3 antibody (ABIN318833)

Target: TNNI3 (Cardiac Troponin I (TNNI3))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This TNNI3 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Product Details anti-TNNI3 Antibody

Specificity: This antibody recognises human cardiac-specific troponin I, (TnI) an integral inhibitory protein of cardiac muscle which exists as a complex with troponin C (TnC) and troponin T (TnT).

Purification: Purified IgG prepared by Immunoaffinity chromatography

Immunogen: Native human cardiac troponin I, purity greater than 98%.

Isotype: IgG

Application Details

Application Notes: ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: PBS buffer pH 7.4 containing 0.09 % Sodium Azide (NaN3)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for TNNI3

Target: TNNI3 (Cardiac Troponin I (TNNI3))

Alternative Name: Cardiac Troponin I

Background: The TnT subunit of troponin binds to tropomyosin to form a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, enabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurement of blood TnI and TnT levels is an important diagnostic indicator of heart muscle damage, and can be used to differentiate between angina and myocardic infarction in patients with chest pain. Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro.Synonyms: TNNC1, TNNI3

Gene ID: 7137

NCBI Accession: NP_000354

UniProt: P19429