PPARD antibody (N-Term)

Catalog No. ABIN318837

The Rabbit Polyclonal anti-PPARD antibody (ABIN318837) specifically detects PPARD in WB and EIA. The antibody is reactive with Human, Mouse, Rat, Rabbit and Monkey samples.

Quick Overview for PPARD antibody (N-Term) (ABIN318837)

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Reactivity: Human, Mouse, Rat, Rabbit, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPARD antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-PPARD Antibody

Binding Specificity: AA 1-14, N-Term

Specificity: This antibody detects peroxisome proliferator-activated receptor, delta (PPARD).

Purification: Purified

Immunogen: Syntetic peptide corresponding to amino acids 1-14 of mouse PPAR delta.

Isotype: IgG

Application Details

Application Notes: ELISA: 1: 2000 - 1: 8000. Western Blot: 1: 500 - 1: 2000, detects a band of approximately 55 kDa in heart whole celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline pH 7.2 containing 0.01 % Sodium Azide (NaN3)

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PPARD

Target: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Alternative Name: PPAR-delta

Background: PPARD is a member of the nuclear hormone receptor subfamily. Upon activation, PPARD forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARD controls genes involved in lipid metabolism, and enhances fatty acid catabolism and energy uncoupling in adipose tissue and skeletal muscle. PPARD has also been implicated in the proliferation and differentiation of preadipocytes, enterocytes, keratinocytes and the placenta. PPARD agonists could be used therapeutically to target multiple components of the metabolic syndrome, including insulin resistance, hyperglycemia, dyslipidemia, and atherosclerosis.Synonyms: NR1C2, NUCI, Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 2, PPAR-beta, PPARB, PPARD, Peroxisome proliferator-activated receptor delta

Gene ID: 19015

NCBI Accession: NP_035275

UniProt: P35396

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation