CEA antibody

Catalog No. ABIN335404

Product Details anti-CEA Antibody

Target: CEA (Carcinoembryonic Antigen Gene Family (CEA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CEA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Human.

Immunogen: PARLAM 4 is a mouse monoclonal IgG1 antibody derived by fusion of Sp 2/0 Ag 14 mouse myeloma cells with spleen cells from a BABL/c mouse immunized with isolated human CEA. The immunogen has been isolated from human colonic carcinoma cells.

Clone: PARLAM 4

Isotype: IgG1

Application Details

Application Notes: Most polyclonal CEA antisera show cross-reactivity with related antigens such as biliary glycoprotein (BGP) and non-specific cross-reacting antigen 1/11 (NCA). PARLAM 4 does not show cross reactivity, neither with BGP nor with NCA. In immunoblotting the antibody recognizes a single band of 180 kD.

Restrictions: For Research Use only

Handling

Storage: 4 °C

References for anti-CEA antibody (ABIN335404)

Taal, Hageman, Delemarre, Bonfrèr, den Hartog Jager: "Metastatic ovarian or colonic cancer: a clinical challenge." in: European journal of cancer (Oxford, England : 1990), Vol. 28, Issue 2-3, pp. 394-9, (1992) (PubMed).

Henzen-Logmans, Schipper, Poels, Stolk, Kenemans, Meyer: "Use of statistical evaluation of antigen profiles in differential diagnosis between colonic and ovarian adenocarcinomas." in: Journal of clinical pathology, Vol. 41, Issue 6, pp. 644-9, (1988) (PubMed).

Verstijnen, Arends, Moerkerk, Warnaar, Hilgers, Bosman: "CEA-specificity of CEA-reactive monoclonal antibodies. Immunochemical and immunocytochemical studies." in: Anticancer research, Vol. 6, Issue 1, pp. 97-104, (1986) (PubMed).

Target Details for CEA

Target: CEA (Carcinoembryonic Antigen Gene Family (CEA))

Alternative Name: Carcinoembryonic Antigen / CEA (CEA Products)

Synonyms: RGD1311281 antibody, carcinoembryonic antigen-related cell adhesion molecule 20 antibody, carcinoembryonic antigen gene family antibody, Ceacam20 antibody, Cea antibody

Background: This monoclonal antibody is reactive with human carcinoembryonic antigen (CEA), a tumour associated antigen with oncofetal characteristics. Although CEA can be found in tissues of non-neoplastic diseases and normal epithelia, it occurs also in a large variety of carcinomas. Therefore, immunohistochemical detection of CEA is frequently used for the histopathological diagnosis of human tumours.