KLKB1 antibody
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- Target See all KLKB1 Antibodies
- KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This KLKB1 antibody is un-conjugated
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Application
- ELISA, Western Blotting (WB)
- Specificity
- Specifically recognizes in human plasma two variants (88 kD and 85 kD) of prekallikrein and its activation products kallikrein (88 kD and 85 kD), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, and 45 kD prekallikrein/kallikrein fragment(s). It also recognizes prekallikrein and its activation products in chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80 % and 55 %, respectively. Does not cross-react with tissue kallikrein.
- Purification
- Protein G purified
- Immunogen
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Human plasma prekallikrein.
Type of Immunogen: Purified protein - Clone
- 13G11
- Isotype
- IgG1
- Top Product
- Discover our top product KLKB1 Primary Antibody
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- Application Notes
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Approved: ELISA, WB
Usage: May be used in ELISA and Western blots to identify/quantitate prekallikrein and its activation products in plasmas of humans, chimpanzees, rhesus monkeys, and baboons. NOTE: Prekallikrein activation may occur with repeated freezing/thawing (3x or more) of plasma samples obtained from humans or other primates. - Comment
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Target Species of Antibody: Human
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- PBS, pH 7.4
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C,-20 °C
- Storage Comment
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- Target
- KLKB1 (Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1))
- Alternative Name
- KLKB1 / Plasma Kallikrein (KLKB1 Products)
- Synonyms
- KLK3 antibody, PPK antibody, APS antibody, Kal-3 antibody, Kal3 antibody, Klk3 antibody, PSA antibody, KALP15 antibody, Kalp1 antibody, KLKB1 antibody, DKFZp459J2015 antibody, klkb1 antibody, kallikrein B1 antibody, kallikrein B, plasma 1 antibody, plasma kallikrein antibody, Plasma kallikrein antibody, kallikrein B, plasma (Fletcher factor) 1 antibody, coagulation factor XI antibody, kallikrein B1 L homeolog antibody, KLKB1 antibody, Klkb1 antibody, CpipJ_CPIJ004042 antibody, CpipJ_CPIJ014955 antibody, CpipJ_CPIJ020108 antibody, VAA_02266 antibody, LOC100549617 antibody, klkb1 antibody, klkb1.L antibody
- Background
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Name/Gene ID: KLKB1
Subfamily: Serine S1
Family: Protease
Synonyms: KLKB1, Fletcher factor deficiency, Fletcher factor, Kininogenin, Plasma kallikrein, PKK deficiency, Plasma kallikrein heavy chain, PPK, Prekallikrein deficiency, Plasma kallikrein light chain, Plasma prekallikrein, Kallikrein 3 - Gene ID
- 3818
- UniProt
- P03952
- Pathways
- Complement System, Brown Fat Cell Differentiation
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