Mre11 antibody (AA 182-582)

Catalog No. ABIN342349

This Mouse Monoclonal antibody specifically detects Mre11 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for Mre11 antibody (AA 182-582) (ABIN342349)

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Mre11 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-Mre11 Antibody

Binding Specificity: AA 182-582

Specificity: Recognizes human Mre11, an 80 kD protein that acts as a Mn+2- dependent double stranded DNA 3' to 5' exonuclease and a single stranded DNA endonuclease. It is part of a larger complex with Rad50, p95 (Nibrin), and possibly other proteins involved in the nucleolytic end-processing of double strand breaks and telomere maintenance.

Purification: Protein G purified

Immunogen: GST fusion protein corresponding to aa 182-582 of Mre11 expressed in E. coli.

Type of Immunogen: Fusion protein

Isotype: IgG1

Application Details

Application Notes: Approved: IP (1 - 5 μg/mL), WB

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4

Handling Advice: Avoid freeze/thaw cycles.

Storage: -80 °C

Storage Comment: Store at -70°C, avoid freeze/thaw cycles.

Target Details for Mre11

Target: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Alternative Name: MRE11A / MRE11

Background: Name/Gene ID: MRE11A

Synonyms: MRE11A, AT-like disease, Endo/exonuclease Mre11, HNGS1, MRE11, MRE11 homolog 1, MRE11 homolog A, MRE11B, ATLD

Gene ID: 4361

UniProt: P49959

Pathways: DNA Damage Repair