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LC3C antibody

MAP1LC3C Reactivity: Human WB, IHC Host: Sheep Polyclonal unconjugated
Catalog No. ABIN350463
  • Target See all LC3C (MAP1LC3C) Antibodies
    LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))
    Reactivity
    • 43
    • 3
    • 2
    Human
    Host
    • 42
    • 1
    Sheep
    Clonality
    • 43
    Polyclonal
    Conjugate
    • 18
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LC3C antibody is un-conjugated
    Application
    • 32
    • 27
    • 9
    • 6
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificity
    Specific for MAP1LC3C.
    Cross-Reactivity
    Human
    Cross-Reactivity (Details)
    Other species not yet tested.
    Purification
    IgG
    Immunogen
    A synthetic peptide from human microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C, MAP1A/MAP1B LC3 C) conjugated to an immunogenic carrier protein has been used as the immunogen.
    Isotype
    IgG
    Top Product
    Discover our top product MAP1LC3C Primary Antibody
  • Application Notes
    IHC, WB. Use at a concentration of 10-50 μg,ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute in 500 μL of sterile water. Centrifuge to remove any insoluble material.
    Handling Advice
    Avoid freeze and thaw cycles.
    Storage
    4 °C/-20 °C
    Storage Comment
    Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
    Expiry Date
    12 months
  • Target
    LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))
    Alternative Name
    MAP1LC3C (MAP1LC3C Products)
    Synonyms
    MAP1LC3C antibody, MGC154878 antibody, ATG8J antibody, LC3C antibody, microtubule associated protein 1 light chain 3 gamma antibody, microtubule associated protein 1 light chain 3 gamma L homeolog antibody, MAP1LC3C antibody, map1lc3c antibody, map1lc3c.L antibody
    Background
    Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. FUNCTION: Probably involved in formation of autophagosomal vacuoles (autophagosomes). SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane, Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane, Lipid-anchor. Note: LC3-II binds to the autophagic membranes. TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.,Mammalian Autophagy,Microtubule-associated proteins 1A/1B light chain 3C, MAP1LC3C, MAP1A/MAP1B LC3 C, MAP1A/1B light chain 3 C, MAP1 light chain 3-like protein 3, Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3C
    UniProt
    Q9BXW4
    Pathways
    Autophagy
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