SORL1 antibody (C-Term)

Catalog No. ABIN350863

Product Details anti-SORL1 Antibody

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Binding Specificity: C-Term

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SORL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purpose: Rabbit antibody to SorLA

Specificity: Specific for SORLA.

Cross-Reactivity: Mouse

Cross-Reactivity (Details): Other species not yet tested.

Purification: IgG

Immunogen: A synthetic peptide from c-terminal of mouse SorLA conjugated to blue carrier protein was used as the antigen.

Isotype: IgG

Application Details

Application Notes: IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handling Advice: Avoid freeze and thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date: 12 months

Target Details for SORL1

Target: SORL1 (Sortilin-Related Receptor, L(DLR Class) A Repeats Containing (SORL1))

Alternative Name: SorLA (SORL1 Products)

Background: FUNCTION: Likely to be a multifunctional endocytic receptor that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL the major cholesterol-carrying lipoprotein of plasma and transports it into cells by endocytosis. Binds the receptor-associated protein (RAP). Could play a role in cell-cell interaction. May play a role in neural organization as well as the establishment of embryonic organ systems. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. TISSUE SPECIFICITY: Abundant in brain where it is mainly expressed in adult cerebellum hippocampal ca regions dentate gyrus and to a much lesser extent in the cerebral cortex. Detectable in kidney skeletal muscle lung and spleen but not in the liver. DEVELOPMENTAL STAGE: Expressed as early as embryonic day 6.5 (E6.5) and peaks at E11 the main location is in the CNS during development. At early stages it is abundant in a subpopulation of neurons in the cerebral cortex in the hippocampus and granular and Purkinje cell layers in the cerebellum whereas in the adult expression in cerebellar granular cells and in the cerebral cortex is low. Expression occurs also in a variety of glands and organs during organogenesis.

UniProt: O88307

Pathways: Smooth Muscle Cell Migration