DEFA5 antibody (cleaved)

Catalog No. ABIN356090

Product Details anti-DEFA5 Antibody

Target: DEFA5 (Defensin, alpha 5, Paneth Cell-Specific (DEFA5))

Binding Specificity: cleaved

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DEFA5 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Aff - Purified

Immunogen: Full-length proHD5 protein. [Swiss-Prot# Q01523] The propeptide is the full-length protein. In the mature form, it is cleaved at residue 63 (alanine).

Clone: 8C8

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for DEFA5

Target: DEFA5 (Defensin, alpha 5, Paneth Cell-Specific (DEFA5))

Alternative Name: Defensin 5 (DEFA5 Products)

Synonyms: DEF5 antibody, HD-5 antibody, Defa29 antibody, Defcr29 antibody, Defcr5 antibody, DEFA1 antibody, DEFA5 antibody, Defa antibody, defensin alpha 5 antibody, defensin, alpha, 5 antibody, defensin, alpha 5, Paneth cell-specific antibody, alpha-defensin 1A antibody, DEFA5 antibody, Defa5 antibody, MNP1A antibody

Background: Human neutrophil alpha-defensins (also designated HNPs) are small, cationic, cysteine-rich antimicrobial proteins that play important roles in innate immunity against infectious microbes such as bacteria, fungi and enveloped viruses. Alpha-defensins are synthesized as inactive precursors and are activated by proteolytic cleavage by MMP-7. Paneth cells in small intestinal crypts secrete the alpha-defensins, which are also termed cryptidins in mice. Alpha-defensins 5 and 6 probably contribute to innate defense of the GI mucosal surface by protecting against microbial invasion in states of intestinal inflammation.

UniProt: Q01523