Factor Inhibiting HIF-1 Antibody (Extracellular Domain), (N-Term) antibody
The Rabbit Polyclonal anti-Factor Inhibiting HIF-1 Antibody antibody is suitable to detect Factor Inhibiting HIF-1 Antibody in samples from Mouse and Rat. It has been validated for ICC, IHC and WB.
Catalog No. ABIN356096
$578.88
Plus shipping costs $50.00
0.1 mL
Shipping to:
United States
Delivery in 2 to 4 Business Days
Quick Overview for Factor Inhibiting HIF-1 Antibody (Extracellular Domain), (N-Term) antibody (ABIN356096)
Target
Factor Inhibiting HIF-1 Antibody
Reactivity
Mouse, Rat
Host
Rabbit
Clonality
Polyclonal
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)
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Binding Specificity
- Extracellular Domain, N-Term
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Cross-Reactivity
- Mouse (Murine), Rat (Rattus)
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Purification
- Aff - Purified
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Immunogen
- Synthetic peptide (Rat) from the N-terminal extracellular domain conjugated to immunogenic carrier protein.
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Isotype
- IgG
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Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Storage
- -20 °C
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- Factor Inhibiting HIF-1 Antibody
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Target Type
- Antibody
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Background
- Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration.
Target
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