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CBLC antibody (C-Term)

CBLC Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN356779
  • Target See all CBLC Antibodies
    CBLC (Cbl proto-oncogene C (CBLC))
    Binding Specificity
    • 9
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 46
    • 2
    • 1
    Human
    Host
    • 41
    • 5
    Rabbit
    Clonality
    • 41
    • 5
    Polyclonal
    Conjugate
    • 26
    • 4
    • 4
    • 4
    • 4
    • 4
    This CBLC antibody is un-conjugated
    Application
    • 45
    • 34
    • 29
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificity
    This antibody is specific to Cbl (C-term).
    Purification
    Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human Cbl-c.
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CBLC Primary Antibody
  • Application Notes
    ELISA: 1/1,000. Western blot: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS containing 0.09 % (W/V) Sodium Azide as preservative.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    CBLC (Cbl proto-oncogene C (CBLC))
    Alternative Name
    CBLC / RNF57 (CBLC Products)
    Synonyms
    CBL-3 antibody, CBL-SL antibody, RNF57 antibody, Cbl proto-oncogene C antibody, CBLC antibody, Cblc antibody
    Background
    Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.Synonyms: CBL-3, CBL-C, CBL3, RING finger protein 57, SH3-binding protein CBL-C, Signal transduction protein CBL-C
    Gene ID
    23624, 9606
    UniProt
    Q9ULV8
    Pathways
    EGFR Signaling Pathway
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