GRM8 antibody (C-Term)

Catalog No. ABIN357164

Product Details anti-GRM8 Antibody

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRM8 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects Metabotropic Glutamate Receptor 8 (GRPRC1H) at C-term.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GRPRC1H.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA 1: 1,000Western blot 1: 100 - 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for GRM8

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Alternative Name: mGluR8 / GRM8 (GRM8 Products)

Synonyms: mGluR8 antibody, GRM8 antibody, MGLUR8 antibody, GLUR8 antibody, GPRC1H antibody, mGlu8 antibody, A230002O04 antibody, Gprc1h antibody, Glur8 antibody, Mglur8 antibody, mGluR8b antibody, mGlur antibody, glutamate metabotropic receptor 8 antibody, metabotropic glutamate receptor 8 antibody, glutamate receptor, metabotropic 8 antibody, GRM8 antibody, MGLUR8 antibody, LOAG_14062 antibody, Grm8 antibody

Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.Synonyms: GPRC1H, Metabotropic glutamate receptor 8

Molecular Weight: 101740 Da

Gene ID: 2918, 9606

UniProt: O00222

Pathways: cAMP Metabolic Process, Synaptic Membrane