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GRM8 antibody (Glutamate Receptor, Metabotropic 8) (C-Term) Primary Antibody

GRM8 Reactivity: Human, Mouse EIA, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN357164
$629.20
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0.4 mL
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Available
  • Target
    GRM8
    Binding Specificity
    • 10
    • 9
    • 4
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 35
    • 21
    • 12
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 31
    • 4
    Rabbit
    Clonality
    • 32
    • 3
    Polyclonal
    Conjugate
    • 16
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRM8 antibody is un-conjugated
    Application
    • 25
    • 20
    • 7
    • 4
    • 3
    • 2
    • 1
    Enzyme Immunoassay (EIA), Western Blotting (WB)
    Specificity
    This antibody detects Metabotropic Glutamate Receptor 8 (GRPRC1H) at C-term.
    Purification
    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
    Immunogen
    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GRPRC1H.
    Isotype
    Ig Fraction
  • Application Notes
    ELISA 1: 1,000Western blot 1: 100 - 1: 500.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.25 mg/mL
    Buffer
    PBS with 0.09 % (W/V) sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target
    GRM8
    Alternative Name
    mGluR8 / GRM8 (GRM8 Antibody Abstract)
    Synonyms
    mGluR8, GRM8, MGLUR8, GLUR8, GPRC1H, mGlu8, A230002O04, Gprc1h, Glur8, Mglur8, mGluR8b, mGlur, glutamate metabotropic receptor 8, metabotropic glutamate receptor 8, glutamate receptor, metabotropic 8, GRM8, MGLUR8, LOAG_14062, Grm8
    Background
    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.Synonyms: GPRC1H, Metabotropic glutamate receptor 8
    Molecular Weight
    101740 Da
    Gene ID
    2918, 9606
    UniProt
    O00222
    Pathways
    cAMP Metabolic Process, Synaptic Membrane
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