USP19 antibody (C-Term)

Catalog No. ABIN357553

This Rabbit Polyclonal antibody specifically detects USP19 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for USP19 antibody (C-Term) (ABIN357553)

Target: USP19 (Ubiquitin Specific Peptidase 19 (USP19))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP19 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-USP19 Antibody

Binding Specificity: AA 1290-1319, C-Term

Specificity: This antibody is specific to Human USP19 (C-term).

Purification: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide between 1290~1319 amino acids from the C-terminal region of human USP19

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for USP19

Target: USP19 (Ubiquitin Specific Peptidase 19 (USP19))

Alternative Name: USP19

Background: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.Synonyms: Deubiquitinating enzyme 19, KIAA0891, Ubiquitin carboxyl-terminal hydrolase 19, Ubiquitin thioesterase 19, Ubiquitin-specific-processing protease 19, ZMYND9, Zinc finger MYND domain-containing protein 9

Molecular Weight: 151340 Da

Gene ID: 10869, 5874

UniProt: O94966