TERT antibody (pSer1125)

Catalog No. ABIN358472

The Rabbit Polyclonal anti-TERT antibody has been validated for EIA. It is suitable to detect TERT in samples from Human.

Quick Overview for TERT antibody (pSer1125) (ABIN358472)

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TERT antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Product Details anti-TERT Antibody

Binding Specificity: pSer1125

Specificity: This antibody detects TERT pSer1125.

Purification: Protein A Chromatography followed by two-step phosphospecific peptide affinity purification.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1125 of human TERT.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Dot Blot: 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for TERT

Target: TERT (Telomerase Reverse Transcriptase (TERT))

Alternative Name: TERT

Background: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks.Synonyms: EST2, HEST2, TCS1, TRT, Telomerase catalytic subunit, Telomerase reverse transcriptase, Telomerase-associated protein 2

Molecular Weight: 126997 Da

Gene ID: 7015, 9606

UniProt: O14746

Pathways: Telomere Maintenance