PARP12 antibody (C-Term)

Catalog No. ABIN358822

This Rabbit Polyclonal antibody specifically detects PARP12 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for PARP12 antibody (C-Term) (ABIN358822)

Target: PARP12 (Poly (ADP-Ribose) Polymerase Family, Member 12 (PARP12))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP12 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-PARP12 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts to PARP12.

Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogen: This PARP12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of mouse PARP12.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for PARP12

Target: PARP12 (Poly (ADP-Ribose) Polymerase Family, Member 12 (PARP12))

Alternative Name: PARP12

Background: Poly(ADP-ribosyl)ation is an immediate DNA-damage-dependent post-translational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. Poly(ADP-ribose) polymerases (PARPs) now constitute a large family of 18 proteins, encoded by different genes and displaying a conserved catalytic domain in which PARP-1 (113 kDa), the founding member, and PARP-2 (62 kDa) are so far the sole enzymes whose catalytic activity has been shown to be immediately stimulated by DNA strand breaks. A large repertoire of sequences encoding novel PARPs now extends considerably the field of poly(ADP-ribosyl)ation reactions to various aspects of the cell biology including cell proliferation and cell death. Some of these new members interact with each other, share common partners and common subcellular localizations suggesting possible fine tuning in the regulation of this post-translational modification of proteins.Synonyms: PARP-12, Poly [ADP-ribose] polymerase 12, ZC3HDC1, Zinc finger CCCH domain-containing protein 1

Gene ID: 243771, 10090

UniProt: Q8BZ20