DUSP14 antibody (N-Term)

Catalog No. ABIN360794

The Rabbit Polyclonal anti-DUSP14 antibody is suitable to detect DUSP14 in samples from Human. It has been validated for IHC (p) and EIA.

Quick Overview for DUSP14 antibody (N-Term) (ABIN360794)

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DUSP14 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-DUSP14 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to DUSP14.

Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human DUSP14.

Isotype: Ig Fraction

Application Details

Application Notes: ELISA: 1/1,000. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for DUSP14

Target: DUSP14 (Dual Specificity Phosphatase 14 (DUSP14))

Alternative Name: DUSP14 / MKP6

Background: DUSP14 is involved in the inactivation of MAP kinases. This protein dephosphorylates ERK, JNK and p38 MAP-kinases. In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28, which interacts with B7-1 and B7-2 ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK and JNK, and the subsequent creation of AP1 transcription factor. DUSP14 is a negative regulator of CD28 signaling.Synonyms: Dual specificity protein phosphatase 14, MAP kinase phosphatase 6, MKP-1-like protein tyrosine phosphatase, Mitogen-activated protein kinase phosphatase 6

Gene ID: 11072, 9606

UniProt: O95147