IL1RL1 antibody (Extracellular Domain)

Catalog No. ABIN360904

This Rat Monoclonal antibody specifically detects IL1RL1 in WB. It exhibits reactivity toward Mouse.

Quick Overview for IL1RL1 antibody (Extracellular Domain) (ABIN360904)

Target: IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL1RL1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 3F22

Product Details anti-IL1RL1 Antibody

Binding Specificity: Extracellular Domain

Specificity: This antibody detects IL-1 R4.

Purification: Protein A/G Affinity Chromatography

Sterility: 0.2 μm filtered

Immunogen: Purified Mouse Recombinant IL-1 R4 extracellular doamin

Isotype: IgG2

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Buffer: Lyophilized from a 0.2 μm filtered solution in PBS

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL1RL1

Target: IL1RL1 (Interleukin 1 Receptor-Like 1 (IL1RL1))

Alternative Name: IL1RL1 / ST2

Background: ST2 is a member of the Toll-Interleukin 1 receptor (TIR) superfamily, expressed by mast cells and TH2 helper cells, but not by TH1 effector cells. The majority of TIR superfamily members, which includes the Interleukin-1 receptor (IL-1R1), Toll-like receptors (TLRs) and the cytosolic adaptor proteins MyD88, TIRAP, Trif and TRAM, initiate innate immunity through the ultimate activation of the transcription factor NF-kappaB and are inducers of the inflammatory response. In contrast ST2, which itself is unable to activate NF-kappaB, has been identified as a negative regulator of IL-1R1 and TLR4 signaling by sequestering MyD88 and TIRAP, in line with its role as a crucial receptor in TH2-cell mediated responses.Synonyms: DER4, FIT-1, Homolog of mouse growth stimulation-expressed, Interleukin-1 receptor-like 1, MGC32623

Gene ID: 17082

NCBI Accession: NP_001020773

UniProt: P14719