IL2 Receptor beta antibody (Extracellular Domain)

Catalog No. ABIN360905

The Rat Monoclonal anti-IL2 Receptor beta antibody is suitable to detect IL2 Receptor beta in samples from Mouse. It has been validated for WB.

Quick Overview for IL2 Receptor beta antibody (Extracellular Domain) (ABIN360905)

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL2 Receptor beta antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 9-00E-033

Product Details anti-IL2 Receptor beta Antibody

Binding Specificity: Extracellular Domain

Specificity: This antibody detects IL-2Rbeta.

Purification: Protein A/G affinity chromatography

Immunogen: Recombinant protein of IL-2Rbeta extracellular domain.

Isotype: IgG2

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL2 Receptor beta

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Alternative Name: CD122 / IL2RB

Background: IL2 Receptor beta (CD122) is a member of the immunoglobulin superfamily that forms the high affinity IL2 receptor with CD25 and CD132. This receptor chain, which is also shared by the IL15 receptor, is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL2 Receptor beta chain can combine with either the common gamma subunit (gamma c) alone or the gamma c subunit and the IL2 Receptor alpha subunit to generate intermediate or high affinity IL2 receptor complexes, respectively. CD122 levels can be upregulated by activation stimuli such as IL2.Synonyms: IL-2 receptor subunit beta, IL2 Receptor beta, Interleukin-2 receptor subunit beta, P70-75

Gene ID: 16185

NCBI Accession: NP_032394

UniProt: P16297

Pathways: JAK-STAT Signaling, Growth Factor Binding