IL21 Receptor antibody (Extracellular Domain)

Catalog No. ABIN360918

This anti-IL21 Receptor antibody is a Rat Monoclonal antibody detecting IL21 Receptor in WB. Suitable for Mouse.

Quick Overview for IL21 Receptor antibody (Extracellular Domain) (ABIN360918)

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IL21 Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 7F27

Product Details anti-IL21 Receptor Antibody

Binding Specificity: Extracellular Domain

Specificity: This antibody detects IL-21R.

Purification: Protein A/G affinity chromatography

Immunogen: Recombinant protein of IL-21R extracellular domain.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for IL21 Receptor

Target: IL21 Receptor (IL21R) (Interleukin 21 Receptor (IL21R))

Alternative Name: Interleukin-21 Receptor / IL21R

Background: IL21 Receptor is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.Synonyms: IL-21R, IL21 receptor, NILR, Novel interleukin receptor

Gene ID: 50615

NCBI Accession: NP_068570

UniProt: Q9HBE5

Pathways: JAK-STAT Signaling