Thymic Stromal Lymphopoietin antibody

Catalog No. ABIN360946

This Rat Monoclonal antibody specifically detects Thymic Stromal Lymphopoietin in WB. It exhibits reactivity toward Mouse.

Quick Overview for Thymic Stromal Lymphopoietin antibody (ABIN360946)

Target: Thymic Stromal Lymphopoietin (TSLP)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Thymic Stromal Lymphopoietin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 5G29

Product Details anti-Thymic Stromal Lymphopoietin Antibody

Specificity: This antibody detects Mouse TSLP. Other species not tested.

Purification: Protein A/G Affinity Chromatography

Immunogen: Purified Mouse Recombinant TSLP

Isotype: IgG2

Application Details

Application Notes: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Buffer: PBS, None

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Thymic Stromal Lymphopoietin

Target: Thymic Stromal Lymphopoietin (TSLP)

Alternative Name: TSLP

Background: Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a mouse thymic stromal cell line that promoted the development of B cells. The activities of mouse TSLP overlap with, but are distinct from, those of mouse IL-7. Both mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells, and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas mouse IL-7 facilitates the development of B220+/IgM- pre-B cells, mouse TSLP promotes the development B220+/IgM+ B cells. Human TSLP was reported to preferentially stimulate myeloid cells, inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c+ dendritic cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence. Within the mature region, six of the seven cysteine residues present in the mouse TSLP involved in intramolecular disulfide bond formation are conserved in the human TSLP. Human TSLP shares approximately 43 % aa sequence identity with mouse TSLP.Synonyms: Thymic stroma-derived lymphopoietin, Thymic stromal lymphopoietin

Gene ID: 53603

NCBI Accession: NP_067342

UniProt: Q9JIE6