THRA antibody (N-Term)

Catalog No. ABIN361383

This anti-THRA antibody is a Mouse Monoclonal antibody detecting THRA in WB. Suitable for Human.

Quick Overview for THRA antibody (N-Term) (ABIN361383)

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This THRA antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 1718

Product Details anti-THRA Antibody

Binding Specificity: N-Term

Specificity: Specific for the ~50k TR-a1 and the ~58k TR-a2 protein.

Cross-Reactivity: Human, Rat (Rattus)

Predicted Reactivity: canine, mouse, non-human primate

Purification: Protein G purified culture supernatant

Immunogen: Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH

Isotype: IgG2a

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

Target Details for THRA

Target: THRA (Thyroid Hormone Receptor, alpha (THRA))

Alternative Name: THRA

Background: Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005, Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRa1, TRa2, TR 1 and TR 2. TRa1, TR 1 and TR 2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005). Anti-Thyroid Hormone Receptor, a1/a2-Isotype Western blot of hippocampal lysate showing specific immunolabeling of the ~50k TR-a1 and the ~58k TR-a2 protein.

Molecular Weight: 50/58 kDa

Gene ID: 7067

UniProt: P10827

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development