RPS6KA2 antibody (C-Term)

Catalog No. ABIN361520

The Rabbit Polyclonal anti-RPS6KA2 antibody has been validated for WB. It is suitable to detect RPS6KA2 in samples from Mouse. There is 1 publication available.

Quick Overview for RPS6KA2 antibody (C-Term) (ABIN361520)

Target: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPS6KA2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-RPS6KA2 Antibody

Binding Specificity: C-Term

Specificity: Specific for the ~90k RSK2 protein.

Cross-Reactivity: Human

Predicted Reactivity: bovine, canine, chicken, mouse, rat

Purification: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH

Application Details

Application Notes: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Storage: -20 °C

References for anti-RPS6KA2 antibody (ABIN361520)

Hegde, Capell, Ibrahim, Klett, Patel, Sougiannis, Kelly: "Phosphodiesterase 11A (PDE11A), Enriched in Ventral Hippocampus Neurons, is Required for Consolidation of Social but not Nonsocial Memories in Mice." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 41, Issue 12, pp. 2920-2931, (2017) (PubMed).

Target Details for RPS6KA2

Target: RPS6KA2 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 2 (RPS6KA2))

Alternative Name: RPS6KA2

Background: The p90 ribosomal S6 kinases (RSK)1–4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin–Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006). Anti-Ribosomal S6 Kinase Western blot of rat hippocampal lysate showing specific immunolabeling of the ~90k RSK2 protein.

Molecular Weight: '90 kDa

Gene ID: 20112

UniProt: Q9WUT3

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Activation of Innate immune Response, Toll-Like Receptors Cascades