CTLA4 antibody

Catalog No. ABIN371057

The Hamster Monoclonal anti-CTLA4 antibody has been validated for FACS, IP and Func. It is suitable to detect CTLA4 in samples from Mouse.

Quick Overview for CTLA4 antibody (ABIN371057)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This CTLA4 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)

Clone: 1B8

Product Details anti-CTLA4 Antibody

Specificity: This Monoclonal antibody is specific to CD152/CTLA-4.

Characteristics: Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4

Endotoxin Level: Low Endotoxin

Isotype: IgG

Application Details

Application Notes: Flow Cytometry. (Ref.1,2)Immunoprecipitation. In vitro Functional Studies. (Ref.1,2)Enhancement of tumor immunity. (Ref.3)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing no preservatives.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquous) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Alternative Name: CD152 / CTLA4

Background: The lymphocyte surface antigen CD152, also known as CTLA-4, is related to the co-stimulatory molecule CD28, and both molecules share common B7 family counter-receptors. (Ref.1-4) However CD152 is thought to be a negative regulator of T cell activation (Ref.1-3) and may play a role in apoptotic control of T cells. CD152 exists as a 69 kDa homodimer (Ref.1), and is relatively conserved among Humans, Mice and Chickens. (Ref.2)Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4

Gene ID: 100505288

UniProt: P09793

Pathways: Cancer Immune Checkpoints