Integrin beta 7 antibody

Catalog No. ABIN371134

This Rat Monoclonal antibody specifically detects Integrin beta 7 in FACS, IHC (fro) and Func. It exhibits reactivity toward Mouse.

Quick Overview for Integrin beta 7 antibody (ABIN371134)

Target: Integrin beta 7 (ITGB7)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin beta 7 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: DATK32

Product Details anti-Integrin beta 7 Antibody

Specificity: This antibody is specific to mouse LPAM1 (Integrin alpha 4 beta 7). It recognises a conformational epitope on the heterodimer.

Characteristics: Synonyms: Integrin alpha-4/beta-7, Integrin alpha 4, Integrin beta 7, ITGA4, ITGB7, LPAM1, CD49d,VLA-4, Lymphocyte Peyer PatchAdhesion Molecule

Endotoxin Level: Low Endotoxin

Immunogen: AKR/Cum mouse spontaneous T lymphoma cell line TK1. (Ref. 1)

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry. (Ref.1-4)Immunohistochemistry on Frozen Sections. (Ref.3)Induction of homotypic cellular aggregation. Blockade of binding to cell adhesion molecules.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing no preservatives.

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store the antibody undiluted in (aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Alternative Name: Integrin beta-7

Background: The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as Integrin alpha 4 beta 7 is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (Ref.1-4)Synonyms: Adhesion Molecule, CD49d, ITGA4, ITGB7, Integrin alpha 4, Integrin alpha-4/beta-7, Integrin beta 7, LPAM1, Lymphocyte Peyer Patch, VLA-4

Gene ID: 16421

UniProt: P26011

Pathways: Integrin Complex