Retinoic Acid Receptor alpha antibody (N-Term)

Catalog No. ABIN371837

The Mouse Monoclonal anti-Retinoic Acid Receptor alpha antibody is suitable to detect Retinoic Acid Receptor alpha in samples from Human, Mouse, Cow and Dog. It has been validated for WB.

Quick Overview for Retinoic Acid Receptor alpha antibody (N-Term) (ABIN371837)

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Reactivity: Human, Mouse, Cow, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This Retinoic Acid Receptor alpha antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 763

Product Details anti-Retinoic Acid Receptor alpha Antibody

Binding Specificity: N-Term

Specificity: This antibody is specific for the ~48k RAR-alpha isotype.

Cross-Reactivity (Details): Species reactivity (expected):Bovine, Canine (Dog) and Mouse.
Species reactivity (tested):Human.

Characteristics: Synonyms: NR1B1, Retinoic acid receptor alpha, Nuclear receptor subfamily 1 group B member 1

Purification: Prepared from Mouse Ascites by Ammonium Sulfate Precipitation followed by Affinity Chromatography on Protein G.

Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of humanretinoic acid receptor, alpha-isotype.

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Retinoic Acid Receptor alpha

Target: Retinoic Acid Receptor alpha (RARA) (Retinoic Acid Receptor, alpha (RARA))

Alternative Name: RAR-alpha / RARA

Background: Retinoic acid (RA, active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXR-alpha, beta and gamma), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).Synonyms: NR1B1, Nuclear receptor subfamily 1 group B member 1, Retinoic acid receptor alpha

Gene ID: 5914

UniProt: P10276

Pathways: Nuclear Receptor Transcription Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, S100 Proteins