ARHGEF11 antibody (N-Term)

Catalog No. ABIN372272

The Rabbit Polyclonal anti-ARHGEF11 antibody is suitable to detect ARHGEF11 in samples from Human, Rat, Mouse, Chicken, Cow, Dog, Horse, Monkey and Chimpanzee. It has been validated for WB and IHC (p).

Quick Overview for ARHGEF11 antibody (N-Term) (ABIN372272)

Target: ARHGEF11 (rho Guanine Nucleotide Exchange Factor (GEF) 11 (ARHGEF11))

Reactivity: Human, Rat, Mouse, Chicken, Cow, Dog, Horse, Monkey, Chimpanzee

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF11 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ARHGEF11 Antibody

Binding Specificity: AA 1-50, N-Term

Specificity: This antibody recognizes Rho Guanine Exchange Factor (GEF) 11 (ARHGEF11).

Cross-Reactivity (Details): Species reactivity (expected):Bovine, Chimpanzee, Chicken, Dog (Canine), Horse, Monkey, Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide corresponding to a portion of the amino acids 1-50 of Human ARHGEF11.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western Blot: 0.1-0.5 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % Sodium Azide as preservative and 0.2 % Gelatin as stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for ARHGEF11

Target: ARHGEF11 (rho Guanine Nucleotide Exchange Factor (GEF) 11 (ARHGEF11))

Alternative Name: ARHGEF11

Background: ARHGEF11 (Rho guanine nucleotide exchange factor 11) acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. It exhibits transforming ability, associates with and modulates the actin cytoskeleton, regulates neurite outgrowth, and mediates activation of Rho in response to stimulation by activated Galpha12/13. Rat ARHGEF11 interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. ARHGEF11 is also thought to be involved in a pathway known to play a role in both insulin secretion and action.Synonyms: GTRAP48, KIAA0380, PDZ-RhoGEF, Rho guanine nucleotide exchange factor 11, RhoGEF glutamate transport modulator GTRAP48

Gene ID: 9826

NCBI Accession: NP_055599

UniProt: O15085

Pathways: Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling