TMEM123 antibody (AA 173-188)

Catalog No. ABIN372449

Product Details anti-TMEM123 Antibody

Target: TMEM123 (Transmembrane Protein 123 (TMEM123))

Binding Specificity: AA 173-188

Reactivity: Human, Mouse, Rat, Cow, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMEM123 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequence: SRRGIRYRTI DEHDAI

Specificity: This antibody recognizes TMEM123/Porimin.

Cross-Reactivity (Details): Species reactivity (expected):Bovine (Cow), Chicken, Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein G Chromatography.

Immunogen: Synthetic peptide corresponding to amino acids 173-188 of human Porimin.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 0.05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for TMEM123

Target: TMEM123 (Transmembrane Protein 123 (TMEM123))

Alternative Name: TMEM123 / Porimin (TMEM123 Products)

Synonyms: KCT3 antibody, PORIMIN antibody, PORMIN antibody, 2310075C12Rik antibody, RGD1305625 antibody, kct3 antibody, pormin antibody, porimin antibody, transmembrane protein 123 antibody, transmembrane protein 123 L homeolog antibody, TMEM123 antibody, Tmem123 antibody, tmem123.L antibody, tmem123 antibody

Background: Porimin was identified by a monoclonal antibody developed by immunizing mice with apoptotic cells. One of these antibodies, designated anti-Porimin (for pro-oncosis receptor inducing membrane injury), was found to directly induce a unique type of cell death in Jurkat cells by binding to a 110- kDa cell surface receptor on Jurkat cells. Anti-Porimin-mediated cell death was preceded by cell aggregation, formation of plasma membrane pores, and the appearance of membrane blebs. More important, these cells show neither DNA fragmentation nor apoptotic bodies, but display lethal damage of the cell membrane.Synonyms: KCT-3, KCT3, Keratinocytes-associated transmembrane protein 3, PSEC0111, Pro-oncosis receptor inducing membrane injury, Transmembrane protein 123

Gene ID: 114908

NCBI Accession: NP_443164

UniProt: Q8N131

Pathways: Regulation of Cell Size