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TAO Kinase 2 antibody (pSer181)
TAOK2
Reactivity: Human, Mouse, Rat, Dog, Xenopus laevis, Finch, Zebrafish (Danio rerio)
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TAO Kinase 2 Antibody
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Target
See all TAO Kinase 2 (TAOK2) Antibodies
TAO Kinase 2 (TAOK2)
Binding Specificity
All epitopes for TAO Kinase 2 antibodies
pSer181
Reactivity
Human, Mouse, Rat, Dog, Xenopus laevis, Finch, Zebrafish (Danio rerio)
Host
All hosts for TAO Kinase 2 antibodies
Rabbit
Clonality
All clonalities for TAO Kinase 2 antibodies
Polyclonal
Conjugate
All conjugates for TAO Kinase 2 antibodies
This TAO Kinase 2 antibody is un-conjugated
Application
All applications for TAO Kinase 2 antibodies
Western Blotting (WB)
Specificity
Specific for the ~120k TAO2 phosphorylated at Ser181 in Western blots. Immunolabeling is completely eliminated by treatment with lambda-phosphatase.
Cross-Reactivity (Details)
Species reactivity (expected):Canine, Finch, Xenopus and Zebrafish. Species reactivity (tested):Human, Mouse and Rat.
Purification
Affinity Chromatography via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser181 of TAO2.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Western blot: 1/1,000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody undiluted (in aliquots) at-20 °C.
Target Details for TAO Kinase 2
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Target
TAO Kinase 2 (TAOK2)
Abstract
TAOK2 Products
Synonyms
MAP3K17 antibody, PSK antibody, PSK1 antibody, PSK1-BETA antibody, TAO1 antibody, TAO2 antibody, Tao2 antibody, 1110033K02Rik antibody, B230344N16 antibody, mKIAA0881 antibody, TAOK2 antibody, map3k17 antibody, psk antibody, psk1 antibody, tao1 antibody, tao2 antibody, TAO kinase 2 antibody, TAO kinase 2 L homeolog antibody, serine/threonine-protein kinase TAO2 antibody, TAOK2 antibody, Taok2 antibody, taok2.L antibody, taok2 antibody, LOC100085396 antibody
Background
In vitro, TAO (thousand and one amino acid) protein kinase 2 (TAO2) activates MAP/ERK kinases (MEKs) 3, 4, and 6 toward their substrates p38 MAP kinase JNK/SAPK (Chen et al., 1999, Chen and Cobb, 2001). This and more recent work has led to the proposal that the TAO protein kinases play an essential role in signaling from physiological agonists to the stress-responsive p38 MAPKs (Chen et al., 2003). Autophosphorylation of TAO may play a role in the mechanism of TAO activation. The MEK binding domain of TAO is autophosphorylated on both serine and threonine residues and Ser181 is located within this domain.Synonyms: KFC-C, KIAA0881, Kinase from chicken homolog C, MAP3K17, PSK-1, PSK1, Prostate-derived STE20-like kinase 1, Serine/threonine-protein kinase TAO2, Thousand and one amino acid protein 2, UNQ2971/PRO7431
Gene ID
9344
NCBI Accession
NP_004774
UniProt
Q9UL54
Pathways
Cell-Cell Junction Organization
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