Reticulon 4 antibody (N-Term)

Catalog No. ABIN372912

This anti-Reticulon 4 antibody is a Rabbit Polyclonal antibody detecting Reticulon 4 in WB, IHC (p) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for Reticulon 4 antibody (N-Term) (ABIN372912)

Target: Reticulon 4 (RTN4)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Reticulon 4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-Reticulon 4 Antibody

Binding Specificity: N-Term

Specificity: This antibody reacts to Neuroendocrine-specific Protein C (RTN4/NOGO).

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic peptide - KLH conjugated corresponding to 23 amino acids from near the amino terminus of Human NOGO-A.

Isotype: IgG

Application Details

Application Notes: ELISA. Western blot: 0.5-1.0 μg/mL. Immunohistochemistry on Paraffin Sections: 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for Reticulon 4

Target: Reticulon 4 (RTN4)

Alternative Name: Reticulon-4 / RTN4

Background: Adult mammalian axon regeneration is generally successful in the peripheral nervous system but poor in the central nervous system. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth inhibitory molecules associated with myelin, the insulating axon sheath. These molecules include NI35, myelin associated glycoprotein, and Nogo (Neurite Outgrowth Inhibitor). Nogo is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in adults.Synonyms: Foocen, KIAA0886, NOGO, NSP, Neurite outgrowth inhibitor, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, Reticulon-5

Gene ID: 57142

NCBI Accession: NP_008939

UniProt: Q9NQC3

Pathways: Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome