GALNS antibody (Internal Region)

Catalog No. ABIN374878

This Goat Polyclonal antibody specifically detects GALNS in WB. It exhibits reactivity toward Human.

Quick Overview for GALNS antibody (Internal Region) (ABIN374878)

Target: GALNS (Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This GALNS antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GALNS Antibody

Binding Specificity: Internal Region

Sequence: C-TTHNLEDHTK LP

Specificity: This antibody detects GALNS.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from the internal region of the protein sequence according to NP_000503.1 Genename: GALNS

Application Details

Application Notes: Peptide ELISA: limit dilution 1: 64000. Western blot: 0.01-0.03 μg/mL. Approx 60 kDa band observed in Human Bone Marrow andPlacenta lysates (calculated MW of 58.0 kDa according to NP_000503.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Target Details for GALNS

Target: GALNS (Galactosamine (N-Acetyl)-6-Sulfate Sulfatase (GALNS))

Alternative Name: GALNS

Background: GALNS (N-acetylgalactosamine-6-sulfatase) is a lysosomal exohydrolase which catalyzes the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder.Synonyms: Chondroitinase, Chondroitinsulfatase, EC=3.1.6.4, GalNAc6S sulfatase, Galactose-6-sulfate sulfatase, N-acetylgalactosamine-6-sulfatase, N-acetylgalactosamine-6-sulfate sulfatase

Gene ID: 2588

NCBI Accession: NP_000503

UniProt: P34059

Pathways: Glycosaminoglycan Metabolic Process