BDKRB1 antibody (Internal Region)

Catalog No. ABIN375179

There is 1 publication for this product available. The Goat Polyclonal anti-BDKRB1 antibody is suitable to detect BDKRB1 in samples from Human. It has been validated for WB and EIA.

Quick Overview for BDKRB1 antibody (Internal Region) (ABIN375179)

Target: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This BDKRB1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-BDKRB1 Antibody

Binding Specificity: Internal Region

Specificity: This antibody reacts to Bradykinin receptor B1.

Purification: Affinity chromatography

Immunogen: Peptide with sequence KVWELYKQCTPK, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/1000. Western Blot: 2 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-BDKRB1 antibody (ABIN375179)

Wu, Roks, Leijten, Garrelds, Musterd-Bhaggoe, van den Bogaerdt, de Maat, Simoons, Danser, Oeseburg: "Genetic variation and gender determine bradykinin type 1 receptor responses in human tissue: implications for the ACE-inhibitor-induced effects in patients with coronary artery disease." in: Clinical science (London, England : 1979), Vol. 126, Issue 6, pp. 441-9, (2014) (PubMed).

Target Details for BDKRB1

Target: BDKRB1 (Bradykinin Receptor B1 (BDKRB1))

Alternative Name: BDKRB1

Background: Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. Bradykinin B1 receptor is generally only minimally expressed under normal physiological conditions, but the expression is induced rapidly under pathologic conditions such as ischemia, atheromatous disease, or exposure to inflammatory cytokines.Synonyms: B1 bradykinin receptor, B1R, BK-1 receptor, BKB1R, BKR1, BRADYB1, Bradykinin B1 Receptor

Gene ID: 623

NCBI Accession: NP_000701

UniProt: P46663

Pathways: ACE Inhibitor Pathway