ITGAL antibody

Catalog No. ABIN375486

Cited in 1 publication. The Mouse Monoclonal anti-ITGAL antibody (Clone 38) (ABIN375486) specifically detects ITGAL in FACS, IP, ELISA, IHC (fro), BR and Adh Act. The antibody is reactive with Human samples.

Quick Overview for ITGAL antibody (ABIN375486)

Target: ITGAL (Integrin alpha-L (ITGAL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ITGAL antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR), Adhesion Activation (Adh Act)

Clone: 38

Product Details anti-ITGAL Antibody

Purpose: Mouse Anti-Human CD11a-LE/AF

Characteristics: Low Endotoxin/Azide Free Anti-Human CD11a antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, ELISA, blocking, and adhesion assays.

Endotoxin Level: Low Endotoxin

Immunogen: Fibronectin purified monocytes

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Preservative: Azide free

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: 2-8°C

References for anti-ITGAL antibody (ABIN375486)

Venet, Ribeiro, Décembre, Bellomo, Joshi, Nuovo, Villard, Cluet, Perret, Pescamona, Paidassi, Walzer, Allatif, Belot, Trouillet-Assant, Ricci, Dreux: "Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2." in: Nature communications, Vol. 14, Issue 1, pp. 694, (2023) (PubMed).

Target Details for ITGAL

Target: ITGAL (Integrin alpha-L (ITGAL))

Alternative Name: CD11a

Background: CD11a, also known as leukocyte function-associated antigen-1 (LFA-1 α ), represents the 180 kDa integrin α L subunit which combines with the CD18 β 2 integrin subunit to form the α L β 2 integrin heterodimer. It is expressed on lymphocytes, granulocytes, monocytes, and macrophages and is upregulated on activated T cells. CD11a/LFA-1 α mediates adhesion of lymphocytes to vascular endothelium and is involved in costimulation.

Gene ID: 3683

UniProt: P20701

Pathways: Activated T Cell Proliferation, Integrin Complex