CD44 antibody (Biotin)

Catalog No. ABIN376015

This Mouse Monoclonal antibody specifically detects CD44 in FACS, IHC, IHC (p) and IP. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for CD44 antibody (Biotin) (ABIN376015)

Target: CD44

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD44 antibody is conjugated to Biotin

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Clone: F10-44-2

Product Details anti-CD44 Antibody (Biotin)

Specificity: Human/Ma's Night Monkey CD44, Mr 80 - 95 kDa

Characteristics: Mouse Anti-Human CD44-BIOT

Purification: Purified

Immunogen: Purified T cells from human lymph nodes

Isotype: IgG2a

Application Details

Application Notes: Working Dilution:
10 µL/10^6 cells
Representative data are included in this product insert.

Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not been tested but use in such assays should not necessarily be excluded.

Restrictions: For Research Use only

Handling

Handling Advice: Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

References for anti-CD44 antibody (Biotin) (ABIN376015)

Caeser, Di Re, Krupka, Gao, Lara-Chica, Dias, Cooke, Fenner, Usheva, Runge, Beer, Eldaly, Pak, Park, Vassiliou, Huntly, Mupo, Bashford-Rogers, Hodson: "Genetic modification of primary human B cells to model high-grade lymphoma." in: Nature communications, Vol. 10, Issue 1, pp. 4543, (2020) (PubMed).

Target Details for CD44

Target: CD44

Alternative Name: CD44

Background: CD44, also known as phagocytic glycoprotein-1 (Pgp-1) and the receptor for hyaluronate, exists as a large number of different isoforms resulting from alternative RNA splicing. The major isoform expressed on lymphocytes, myeloid cells and erythrocytes is a glycosylated type I transmembrane protein. Other variable isoforms containing glycosaminoglycans have molecular weights ranging from 110 to 250 kDa and are widely expressed on hematopoietic and non-hematopoietic cells. CD44 contributes to the adhesion of leukocytes to endothelial cells, stromal cells and the extracellular matrix. It also plays a functional role in cell migration, lymphocyte homing and adhesion during hematopoiesis and lymphocyte activation.

Pathways: Glycosaminoglycan Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling