This antibody is purified through a protein G column, followed by dialysis against PBS.
This monoclonal antibody is generated from mice immunized with a KLH conjugated synthetic peptide corresponding to sequences in Tyr1234/1235 region of human Met and residues both Tyr1234 and Tyr1235 are phosphorylated.
AUTS9, HGFR, RCCP2, c-Met, AI838057, HGF, Par4, Hgfr, c-met, MET, C-MET, met, met-A, MET proto-oncogene, receptor tyrosine kinase, met proto-oncogene, MET proto-oncogene, receptor tyrosine kinase L homeolog, MET, Met, met.L
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene.