c-MET antibody (AA 25-150)

Catalog No. ABIN671661

Cited in 5+ publications. The Rabbit Polyclonal anti-c-MET antibody (ABIN671661) specifically detects c-MET in WB, IF, IHC (p) and IHC (fro). The antibody is reactive with Mouse samples.

Quick Overview for c-MET antibody (AA 25-150) (ABIN671661)

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This c-MET antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-c-MET Antibody

Binding Specificity: AA 25-150

Purpose: MET Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from mouse MET

Isotype: IgG

Application Details

Application Notes: WB(1:500-2000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-c-MET antibody (ABIN671661)

Wang, Tang, Shen, Chen, Chen, Luo, Ge: "Hepatocyte growth factor (HGF) optimizes oral traumatic ulcer healing of mice by reducing inflammation." in: Cytokine, Vol. 99, pp. 275-280, (2018) (PubMed).

Yu, He, Jiang, He, Fan, Wang, Geng, Dong: "Expression and tissue distribution of hepatocyte growth factor (HGF) and its receptor (c-Met) in alpacas (Vicugna pacos) skins associated with white and brown coat colors." in: Acta histochemica, (2015) (PubMed).

Li, Zhang, Zhao, Shi, Yao, Zhang, Guo, Liu: "Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer." in: Oncology letters, Vol. 9, Issue 5, pp. 1989-1996, (2015) (PubMed).

Gao, Bing, Li, Yang, Li, Chen: "Study of critical role of c-Met and its inhibitor SU11274 in colorectal carcinoma." in: Medical oncology (Northwood, London, England), Vol. 30, Issue 2, pp. 546, (2013) (PubMed).

Guo, Yang, Yao, Zhang, Da, Duan: "Expression of MACC1 and c-Met in human gastric cancer and its clinical significance." in: Cancer cell international, Vol. 13, Issue 1, pp. 121, (2013) (PubMed).

Target Details for c-MET

Target: c-MET (MET) (Met Proto-Oncogene (MET))

Alternative Name: Met (c-Met)

Background:

Synonyms: MET_HUMAN, Hepatocyte growth factor receptor, EC:2.7.10.1, HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor(SF receptor), Tyrosine-protein kinase Met, MET proto-oncogene, receptor tyrosine kinase, DA11, HGFR, AUTS9, RCCP2, c-Met, c Met, DFNB97,

Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]

Gene ID: 4233

UniProt: P16056

Pathways: RTK Signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor