SENP1 antibody (C-Term)

Catalog No. ABIN388043

The Rabbit Polyclonal anti-SENP1 antibody has been validated for WB. It is suitable to detect SENP1 in samples from Human. There are 2+ publications available.

Quick Overview for SENP1 antibody (C-Term) (ABIN388043)

Target: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SENP1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB00649-RB0650

Product Details anti-SENP1 Antibody

Binding Specificity: AA 560-590, C-Term

Predicted Reactivity: M

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SENP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 560-590 amino acids from the C-terminal region of human SENP1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-SENP1 antibody (ABIN388043)

Rohira, Chen, Allen, Johnson: "Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression." in: The Journal of biological chemistry, Vol. 288, Issue 26, pp. 19288-95, (2013) (PubMed).

Meinecke, Cinski, Baier, Peters, Dankbar, Wille, Drynda, Mendoza, Gay, Hay, Ink, Gay, Pap: "Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 12, pp. 5073-8, (2007) (PubMed).

Target Details for SENP1

Target: SENP1 (SUMO1/sentrin Specific Peptidase 1 (SENP1))

Alternative Name: SENP1

Background: SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.

Molecular Weight: 73481

Gene ID: 29843

NCBI Accession: NP_001254523, NP_001254524

UniProt: Q9P0U3

Pathways: Positive Regulation of Endopeptidase Activity