SUV39H2 antibody (C-Term)

Catalog No. ABIN388082

The Rabbit Polyclonal anti-SUV39H2 antibody is suitable to detect SUV39H2 in samples from Human and Rat. It has been validated for WB and IHC (p).

Quick Overview for SUV39H2 antibody (C-Term) (ABIN388082)

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SUV39H2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB02739

Product Details anti-SUV39H2 Antibody

Binding Specificity: AA 360-390, C-Term

Predicted Reactivity: Pr

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SUV39H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-390 amino acids from the C-terminal region of human SUV39H2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze-thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.

Expiry Date: 6 months

Target Details for SUV39H2

Target: SUV39H2 (Suppressor of Variegation 3-9 Homolog 2 (Drosophila) (SUV39H2))

Alternative Name: SUV39H2

Background: The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59 % identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.

Molecular Weight: 46682

Gene ID: 79723

NCBI Accession: NP_001180353, NP_001180354, NP_001180355, NP_001180356, NP_078946

UniProt: Q9H5I1