RFC2 antibody (N-Term)

Catalog No. ABIN389297

The Rabbit Polyclonal anti-RFC2 antibody is suitable to detect RFC2 in samples from Human. It has been validated for WB, FACS and IHC (p).

Quick Overview for RFC2 antibody (N-Term) (ABIN389297)

Target: RFC2 (Replication Factor C (Activator 1) 2, 40kDa (RFC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFC2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB17303

Product Details anti-RFC2 Antibody

Binding Specificity: AA 17-46, N-Term

Predicted Reactivity: B, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RFC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of human RFC2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for RFC2

Target: RFC2 (Replication Factor C (Activator 1) 2, 40kDa (RFC2))

Alternative Name: RFC2

Background: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. RFC2 is the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of RFC2 gene has been associated with Williams syndrome.

Molecular Weight: 39157

Gene ID: 5982

NCBI Accession: NP_001265720, NP_001265721, NP_001265722, NP_002905, NP_852136

UniProt: P35250

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA