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LC3C antibody (pSer12)

MAP1LC3C Reactivity: Human WB, DB Host: Rabbit Polyclonal RB10838-RB16769 unconjugated
Catalog No. ABIN389699
  • Target See all LC3C (MAP1LC3C) Antibodies
    LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))
    Binding Specificity
    • 15
    • 13
    • 8
    • 6
    • 2
    • 2
    • 2
    • 1
    pSer12
    Reactivity
    • 43
    • 3
    • 2
    Human
    Host
    • 41
    • 1
    • 1
    Rabbit
    Clonality
    • 43
    Polyclonal
    Conjugate
    • 18
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This LC3C antibody is un-conjugated
    Application
    • 32
    • 27
    • 8
    • 7
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), Dot Blot (DB)
    Predicted Reactivity
    Zf, B, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This LC3C Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S12 of human LC3C.
    Clone
    RB10838-RB16769
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000. WB: 1:1000. WB: 1:1000. WB: 1:1000. DB: 1:500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Tanaka, Koyama, Sakurai, Kamiyoshi, Ichikawa-Shindo, Kawate, Liu, Xian, Imai, Zhai, Hirabayashi, Owa, Yamauchi, Igarashi, Taniguchi, Shindo: "The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis." in: Cardiovascular research, Vol. 111, Issue 4, pp. 398-409, (2017) (PubMed).

    Xie, Kang, Tang: "Assessment of Posttranslational Modifications of ATG proteins." in: Methods in enzymology, Vol. 587, pp. 171-188, (2017) (PubMed).

    Li, Liu, Wang, Wang, Zhao, Su, Zhang, Zhang, Xu, Zhao, Miao: "Identification of a small molecule targeting annexin A7." in: Biochimica et biophysica acta, Vol. 1833, Issue 9, pp. 2092-9, (2013) (PubMed).

    Colecchia, Strambi, Sanzone, Iavarone, Rossi, DallArmi, Piccioni, Verrotti di Pianella, Chiariello: "MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins." in: Autophagy, Vol. 8, Issue 12, pp. 1724-40, (2012) (PubMed).

    Su, Chao, Huang, Weng, Jeng, Lai: "Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy." in: Journal of virology, Vol. 85, Issue 20, pp. 10561-71, (2011) (PubMed).

    Cherra, Kulich, Uechi, Balasubramani, Mountzouris, Day, Chu: "Regulation of the autophagy protein LC3 by phosphorylation." in: The Journal of cell biology, Vol. 190, Issue 4, pp. 533-9, (2010) (PubMed).

  • Target
    LC3C (MAP1LC3C) (Microtubule-Associated Protein 1 Light Chain 3 gamma (MAP1LC3C))
    Alternative Name
    LC3C (MAP1LC3C Products)
    Synonyms
    MAP1LC3C antibody, MGC154878 antibody, ATG8J antibody, LC3C antibody, microtubule associated protein 1 light chain 3 gamma antibody, microtubule associated protein 1 light chain 3 gamma L homeolog antibody, MAP1LC3C antibody, map1lc3c antibody, map1lc3c.L antibody
    Background
    MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole).
    Molecular Weight
    14272
    Gene ID
    84557
    NCBI Accession
    NP_115903, NP_852610
    UniProt
    Q9H492
    Pathways
    Autophagy
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