RAPTOR antibody (pSer863)

Catalog No. ABIN389879

Product Details anti-RAPTOR Antibody

Target: RAPTOR

Binding Specificity: pSer863

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAPTOR antibody is un-conjugated

Application: Western Blotting (WB), Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Raptor Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.

Clone: RB24817-24818

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:500. IHC-P: 1:100. DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-RAPTOR antibody (ABIN389879)

Cully, Genevet, Warne, Treins, Liu, Bastien, Baum, Tapon, Leevers, Downward: "A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1." in: Molecular and cellular biology, Vol. 30, Issue 2, pp. 481-95, (2009) (PubMed).

Target Details for RAPTOR

Target: RAPTOR

Alternative Name: Raptor (RAPTOR Products)

Synonyms: KOG1 antibody, Mip1 antibody, 4932417H02Rik antibody, Rap antibody, Raptor antibody, mKIAA1303 antibody, RGD1311784 antibody, regulatory associated protein of MTOR complex 1 antibody, regulatory associated protein of MTOR, complex 1 antibody, RPTOR antibody, Rptor antibody

Background: Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.

Molecular Weight: 149038

Gene ID: 57521

NCBI Accession: NP_065812

UniProt: Q8N122

Pathways: Warburg Effect