SNCA antibody (C-Term)

Catalog No. ABIN390368

The Rabbit Polyclonal anti-SNCA antibody has been validated for WB. It is suitable to detect SNCA in samples from Human and Mouse.

Quick Overview for SNCA antibody (C-Term) (ABIN390368)

Target: SNCA (Synuclein, alpha (SNCA))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNCA antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB7377

Product Details anti-SNCA Antibody

Binding Specificity: AA 104-133, C-Term

Predicted Reactivity: B, Pr, Pig

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This SNCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the C-terminal region of human SNCA.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for SNCA

Target: SNCA (Synuclein, alpha (SNCA))

Alternative Name: alpha Synuclein

Background: Alpha Synuclein is implicated in the regulation of dopamine release and transport. It is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). In the nervous system, alpha Synuclein is primarily located at presynaptic terminals and is found membrane bound in dopaminergic neurons. It can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies), including Parkinson's Disease. Alpha Synuclein induces fibrillization of microtubule associated protein tau and reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase 3 activation. Alpha synuclein is a protein phosphorylated predominantly on serine residues. Two alternatively spliced transcripts of Alpha Synuclein have been identified. Additional splicing may be present but the full-length nature of these variants has not been determined. This variant (NACP140) is the longer transcript and encodes the longer isoform (NACP140). This antibody specific recognizing Alpha-synuclein isoform NACP140 not NACP112.

Molecular Weight: 14460

Gene ID: 6622

NCBI Accession: NP_000336, NP_001139526, NP_001139527, NP_009292

UniProt: P37840

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity