MTM1 antibody (C-Term)

Catalog No. ABIN390784

This Rabbit Polyclonal antibody specifically detects MTM1 in WB. It exhibits reactivity toward Human and Mouseand has been mentioned in 1 publication.

Quick Overview for MTM1 antibody (C-Term) (ABIN390784)

Target: MTM1 (Myotubularin 1 (MTM1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTM1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB0856

Product Details anti-MTM1 Antibody

Binding Specificity: AA 566-594, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 566-594 amino acids from the C-terminal region of human MTM1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-MTM1 antibody (ABIN390784)

Jian, Cheng, Jiang, Deng, Hu, Zhang: "A cDNA-based random RNA interference library for functional genetic screens in embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 8, pp. 1904-12, (2007) (PubMed).

Target Details for MTM1

Target: MTM1 (Myotubularin 1 (MTM1))

Alternative Name: MTM1

Background: MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.

Molecular Weight: 69932

Gene ID: 4534

NCBI Accession: NP_000243

UniProt: Q13496

Pathways: Inositol Metabolic Process, Skeletal Muscle Fiber Development