PANK2 antibody (N-Term)

Catalog No. ABIN391237

This Rabbit Polyclonal antibody specifically detects PANK2 in WB. It exhibits reactivity toward Human.

Quick Overview for PANK2 antibody (N-Term) (ABIN391237)

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PANK2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB5486

Product Details anti-PANK2 Antibody

Binding Specificity: AA 65-95, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PANK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-95 amino acids from the N-terminal region of human PANK2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for PANK2

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Alternative Name: PANK2

Background: Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA is the major acyl carrier, playing a central role in intermediary and fatty acid metabolism. In both yeast and fly, each with only 1 pantothenate kinase gene, the null mutant is inviable. Mutations in PANK2 are the cause of pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS). PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain. Mutations in PANK2 are the cause of hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).

Molecular Weight: 62681

Gene ID: 80025

NCBI Accession: NP_079236, NP_705902, NP_705904

UniProt: Q9BZ23

Pathways: Ribonucleoside Biosynthetic Process