PANK2 antibody

Catalog No. ABIN7230484

The Rabbit Polyclonal anti-PANK2 antibody (ABIN7230484) specifically detects PANK2 in WB and ELISA. The antibody is reactive with Human and Mouse samples.

Quick Overview for PANK2 antibody (ABIN7230484)

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PANK2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PANK2 Antibody

Purpose: Rabbit Anti-PANK2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of PANK2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human PANK2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for PANK2

Target: PANK2 (Pantothenate Kinase 2 (PANK2))

Alternative Name: PANK2

Background: Pantothenate kinase 2, mitochondrial, hPanK2, Pantothenic acid kinase 2PANK2 gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.

Molecular Weight: 62kD

Gene ID: 80025

UniProt: Q9BZ23

Pathways: Ribonucleoside Biosynthetic Process